A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61P 35/00 (2006.01) C07K 16/28 (2006.01)
Patent
CA 2697612
The invention relates to antibodies which bind to insulin like growth factor receptor -1 (IGF-IR) and uses thereof, in particular in the diagnosis and treatment of cancer. Specific human and murine monoclonal antibodies which inhibit IGF-1R-mediated pro-survival and tumor proliferation pathways, and variants, fragments, and derivatives thereof are provided. Also provided are specific human and murine monoclonal antibodies capable of synergistically inhibiting the ability of the ligands, insulin like growth factor 1(IGF-I) and insulin like growth factor 2 (IGF-2), to bind to IGF-IR; as well as fragments, variants and derivatives of such antibodies. Antibodies of the invention produce such synergistic effects via allosteric and/or competitive inhibition of IGF-IR ligand binding.
L'invention concerne des anticorps qui se lient au récepteur du facteur de croissance analogue à l'insuline-1 (IGF-IR) et ses utilisations, en particulier dans le diagnostic et le traitement du cancer. Elle concerne des anticorps monoclonaux humains et murins spécifiques qui inhibent les voies de survie et de prolifération tumorale médiées par IGF-lR, et des variants, des fragments et des dérivés de ceux-ci. Elle concerne également des anticorps monoclonaux humains et murins spécifiques capables d'inhiber en synergie la capacité des ligands, facteur de croissance analogue à l'insuline-1 (IGF-I) et facteur de croissance analogue à l'insuline-2 (IGF-2), à se lier à IGF-IR; ainsi que des fragments, des variants et des dérivés de ces anticorps. Les anticorps de l'invention produisent ces effets synergiques par inhibition allostérique et/ou compétitive de la liaison des ligands d'IGF-IR.
Demarest Stephen
Hariharan Kandasamy
Biogen Idec Ma Inc.
Gowling Lafleur Henderson Llp
LandOfFree
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