Anti-igf antibodies

Details Anti-igf antibodies Anti-igf antibodies

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61P 35/00 (2006.01) C07K 16/22 (2006.01)

Patent

CA 2740341

Antibody molecules, in particular fully human antibodies that bind to human IGF-1 and cross-react with IGF-2 such that binding of IGF-1 and IGF-2 to the IGF-1 receptor is prevented and IGF-1 receptor-mediated signaling is inhibited. The antibodies do not bind to insulin and thus do not affect the mitogenic properties of insulin that are mediated by its binding to the insulin receptors. The antibodies are useful for the treatment of hyperproliferative diseases, in particular cancer.

L'invention concerne des molécules d'anticorps, en particulier des anticorps entièrement humains qui se lient à l'IGF-1 humain et produisent une réaction croisée avec l'IGF-2 qui empêche la liaison d'IGF-1 et d'IGF-2 au récepteur d'IGF-1 et inhibe la signalisation induite par les récepteurs d'IGF-1. Ces anticorps ne se lient pas à l'insuline, et, de ce fait, n'agissent pas sur les propriétés mitogènes de l'insuline qui dépendent de sa liaison aux récepteurs de l'insuline. Lesdits anticorps sont utiles dans le traitement de maladies hyperprolifératives, le cancer en particulier.

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