Anti-il-12/il-23 antibodies

Details Anti-il-12/il-23 antibodies Anti-il-12/il-23 antibodies

C - Chemistry, Metallurgy

07

K

C07K 16/24 (2006.01) A61K 39/395 (2006.01) A61P 1/00 (2006.01) A61P 1/02 (2006.01) A61P 1/16 (2006.01) A61P 3/08 (2006.01) A61P 5/14 (2006.01) A61P 7/00 (2006.01) A61P 9/00 (2006.01) A61P 9/10 (2006.01) A61P 11/00 (2006.01) A61P 13/12 (2006.01) A61P 17/00 (2006.01) A61P 17/06 (2006.01) A61P 17/14 (2006.01) A61P 19/02 (2006.01) A61P 19/04 (2006.01) A61P 19/10 (2006.01) A61P 25/28 (2006.01) A61P 27/00 (2006.01) A61P 27/02 (2006.01) A61P 29/00 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) A61P 37/08 (200

Patent

CA 2733642

The present invention provides an antibody comprising an antigen binding domain which binds to human IL-12 and human IL-23. The antibody binds human IL-12p40 existing as a monomer (human IL-12p40) and as a homodimer (human IL-12p80) and the antibody inhibits the binding of human IL-12 to human IL-12R .beta.2 and human IL-23 to human IL-23R but does not inhibit the binding of human IL-12 or human IL-23 or human IL-12p40 or human IL- 12p80 to human IL-12R(.beta.1.

La présente invention porte sur un anticorps comportant un domaine de liaison à un antigène qui se lie à IL-12 humain et IL-23 humain. L'anticorps se lie à IL-12p40 humain existant sous forme de monomère (IL-12p40 humain) et sous forme d'homodimère (IL-12p80 humain) et l'anticorps empêche la liaison de IL-12 humain à IL-12R ß2 humain et IL-23 humain à IL-23R humain mais n'empêche pas la liaison de IL-12 humain ou IL-23 humain ou IL-12p40 humain ou IL-12p80 humain à IL-12Rß1 humain.

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