C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) C07K 14/715 (2006.01)
Patent
CA 2596390
The present invention relates to blocking, inhibiting, reduceing, antagonizing or neutralizing the activity of IL-22, IL-20, or both IL-20 and IL-22 polypeptide molecules. IL-20 and IL-22 are cytokines that are involved in inflammatory processes and human disease. IL-22RA (zcytor11) is a common receptor for IL-20 and IL-22. The present invention includes anti-IL-22RA antibodies and binding partners, as well as methods for antagonizing IL-22 or both IL-20 and IL-22 using such antibodies and binding partners.
L'invention concerne le blocage, l'inhibition, la réduction, l'antagonisation ou la neutralisation de l'activité de molécules polypeptidiques IL-22, IL-20, ou IL-20 et IL-22. IL-20 et IL-22 sont des cytokines impliquées dans des processus inflammatoires et dans des maladies humaines. IL-22RA (zcytor11) est un récepteur commun pour IL-20 et IL-22. L'invention concerne également des anticorps et des partenaires de liaison anti-IL-22RA, ainsi que des méthodes d'antagonisation d'IL-22 ou d'IL-20 et d'IL-22 au moyen de ces anticorps et partenaires de liaison.
Xu Wenfeng
Osler Hoskin & Harcourt Llp
Zymogenetics Inc.
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