Anti-il-22ra antibodies and binding partners and methods of...

Details Anti-il-22ra antibodies and binding partners and methods of... Anti-il-22ra antibodies and binding partners and methods of...

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) C07K 14/715 (2006.01)

Patent

CA 2584157

The present invention relates to blocking, inhibiting, reduceing, antagonizing or neutralizing the activity of IL-22, IL-20, or both IL-20 and IL-22 polypeptide molecules. IL-20 and IL-22 are cytokines that are involved in inflammatory processes and human disease. IL-22RA (zcytor11) is a common receptor for IL-20 and IL-22. The present invention includes anti-IL-22RA antibodies and binding partners, as well as methods for antagonizing IL-22 or both IL-20 and IL-22 using such antibodies and binding partners.

La présente invention concerne une méthode permettant de bloquer, d'inhiber, de réduire, d'antagoniser ou de neutraliser l'activité de molécules polypeptidiques IL-20 et/ou IL-22. L'IL-20 et l'IL-22 sont des cytokines qui sont impliquées dans les processus inflammatoires et la maladies humaine. L'IL-22RA (zcytor11) est un récepteur commun pour l'IL-20 et l'IL-22. La présente invention concerne également des anticorps anti-IL-22RA et des partenaires de liaison, ainsi que des méthodes permettant d'antagoniser l'IL-22 ou à la fois l'IL-20 et l'IL-22, dans lesquelles sont utilisés ces anticorps et ces partenaires de liaison.

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