Anti-il-6 antibodies, compositions, methods and uses

Details Anti-il-6 antibodies, compositions, methods and uses Anti-il-6 antibodies, compositions, methods and uses

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A01H 5/00 (2006.01) A01K 67/00 (2006.01) A61K 39/395 (2006.01) A61M 37/00 (2006.01) C07H 21/04 (2006.01) C07K 16/00 (2006.01) C07K 16/24 (2006.01) C07K 16/46 (2006.01) C12N 15/00 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2467719

The present invention relates to at least one novel chimeric, humanized or CDR- grafted anti-IL-6 antibodies derived from the murine CLB-8 antibody, including isolated nucleic acids that encode at least one such anti-IL-6 antibody, vectors, host cells, transgenic animals or plants, methods of making and using thereof, including therapeutic compositions, methods and devices.

L'invention concerne au moins un nouvel anticorps anti-IL-6 chimère, humanisé ou auquel a été greffée une région déterminant la complémentarité (CDR) dérivée de l'anticorps murin CLB-8, ainsi que des acides nucléiques isolés qui codent au moins ledit anticorps anti-IL-6, des vecteurs, des cellules hôtes, des animaux ou des plantes transgéniques, des méthodes de production et d'utilisation de celui-ci, et des compositions thérapeutiques, des méthodes et des dispositifs associés.

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