Anti-il-6 monoclonal antibodies and uses thereof

Details Anti-il-6 monoclonal antibodies and uses thereof Anti-il-6 monoclonal antibodies and uses thereof

C - Chemistry, Metallurgy

07

K

C07K 16/24 (2006.01) A61K 39/395 (2006.01) A61P 19/02 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2657763

The present invention provides novel monoclonal antibodies that bind specifically to IL- 6. The antibodies of the invention comprise a variable heavy chain (VH) region selected from any of the VH regions disclosed herein as well as amino acid variants thereof, and/or a variable light chain (VL) region selected from any of the VL regions disclosed herein as well as amino acid variants thereof. The invention also provides methods of treating diseases and disorders associated with IL-6 expression and/or activity.

La présente invention concerne de nouveaux anticorps monoclonaux qui se lient spécifiquement à l'IL-6. Les anticorps de l'invention comportent une région variable de chaîne lourde (VH) choisie parmi n'importe laquelle des régions VH décrites dans ce document aussi bien que des variants d'acide aminé de celles-ci, et/ou une région variable de chaîne légère (VL) choisie parmi n'importe laquelle des régions VL décrites dans ce document aussi bien que des variants d'acide aminé de celles-ci. L'invention concerne également des procédés de traitement de maladies et de troubles associés à l'expression et/ou l'activité de IL-6.

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