Anti-il13 receptor .alpha.1 neutralizing antibody

Details Anti-il13 receptor .alpha.1 neutralizing antibody Anti-il13 receptor .alpha.1 neutralizing antibody

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) C12N 5/20 (2006.01) C12N 15/00 (2006.01) C12P 21/08 (2006.01) G01N 33/53 (2006.01) G01N 33/563 (2006.01) G01N 33/577 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2468950

A novel anti-IL13 receptor .alpha.1 antibody having an activity of inhibiting the cell response by IL13, in particular, having an activity of inhibiting the cell response by IL13 but not inhibiting the cell response by IL4; the characteristic amino acid sequence in the variable region thereof; and a method of detecting IL13 receptor .alpha.1 in a sample using the same.

L'invention concerne un nouvel anticorps anti-récepteur .alpha.1 de l'IL13 qui produit un effet inhibiteur sur la réponse cellulaire par IL13, et qui produit plus particulièrement un effet inhibiteur sur la réponse cellulaire par IL13 mais par sur la réponse cellulaire par IL4. L'invention concerne en outre la séquence d'acides aminés caractéristique située dans la région variable de celui-ci ; ainsi qu'un procédé de détection du récepteur .alpha.1 de l'IL13 dans un échantillon au moyen de cet anticorps.

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