Anti-infection and antithrombogenic medical articles and...

A - Human Necessities – 61 – L

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A61L 33/00 (2006.01) A61L 27/00 (2006.01) A61L 27/34 (2006.01) A61L 27/54 (2006.01) A61L 29/00 (2006.01) A61L 29/06 (2006.01) A61L 29/08 (2006.01) A61L 29/16 (2006.01) A61L 31/10 (2006.01) A61L 31/16 (2006.01)

Patent

CA 2004366

An anti-infective medical article has chlorhexidine bulk distributed throughout a polyurethane base layer and may have a coating layer on the base layer. The coating layer may be chlorhexidine permeated into the surface or it may be an antibiotic, antithrombogenic agent or a polymeric surface layer laminated onto the base layer. The invention includes a method for preparing the article wherein a homogeneous melt of polymer and chlorhexidine is prepared by twin screw compounding and the melt is extruded to give a medical article having bulk distributed chlorhexidine.

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