C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 501/00 (2006.01) A61K 31/545 (2006.01) A61K 31/546 (2006.01) A61P 31/04 (2006.01)
Patent
CA 2401151
The present invention provides compositions and methods for targeting toxic anti-metabolites to inhibit the growth of antibiotic resistant microbial infections. It provides a means of taking advantage of a key disease resistance mechanism to activate these drugs locally, and to overcome the resistance phenotype of the microbes. In addition, the invention provides methods for treating a subject infected with an antibiotic resistant microorganism by administering the compounds or compositions of the invention.
L'invention concerne des compositions et des procédés servant à cibler des anti-métabolites toxiques afin d'inhiber l'évolution d'infections microbiennes résistantes aux antibiotiques. Elle concerne des moyens permettant de mettre avantageusement en application un mécanisme clé de résistance à la maladie dans le but d'activer localement ces médicaments et d'annihiler le phénotype de résistance des microbes. Elle concerne, de plus, des procédés servant à traiter un individu infecté par un micro-organisme résistant aux antibiotiques et consistant à administrer ces composés ou ces compositions.
Cathers Brian Edwin
Chan Ming Fai
Doppalapudi Venkata Ramana
Hixon Mark Stephen
Lobl Thomas J.
Borden Ladner Gervais Llp
Newbiotics Inc.
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