Anti-inflammatory 1-heteroaryl-3-acyl-2-oxindoles

Details Anti-inflammatory 1-heteroaryl-3-acyl-2-oxindoles Anti-inflammatory 1-heteroaryl-3-acyl-2-oxindoles

C - Chemistry, Metallurgy

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C07D 405/00 (2006.01) A61K 31/425 (2006.01) C07D 405/04 (2006.01) C07D 405/14 (2006.01) C07D 409/00 (2006.01) C07D 409/04 (2006.01) C07D 409/14 (2006.01) C07D 417/04 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2007655

Certain 1-heteroaryl-3-acyl-2-oxindoles wherein the acyl-substituent is thenoyl, furoyl, benzoyl or substituted benzoyl, are inhibitors of cycloxygenase and lipoxygenase enzymes and are useful as anti-inflam- matory agents in mammals. (I) Image [wherein R1 is thienyl, furyl or 2-thiazolyl; R2 is thienyl, furyl or Image (in which X is H, F, Cl C1-4alkyl, C1-4alkoxy, C1-4alkylthio, nitro of CF3, and Y is H, F, or Cl); and R3 and R4 may be the same or different and each are H, F, Cl, Br, C1-4alkyl, C1-4alkoxy, C1-4alkylthio, nitro or CF3].

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