Anti-inflammatory 1-heteroaryloxindole-3-carboxamides

Details Anti-inflammatory 1-heteroaryloxindole-3-carboxamides Anti-inflammatory 1-heteroaryloxindole-3-carboxamides

C - Chemistry, Metallurgy

07

D

C07D 405/00 (2006.01) A61K 31/425 (2006.01) C07D 409/00 (2006.01) C07D 417/00 (2006.01)

Patent

CA 2007651

Certain N-(substituted)-1-heteroaryl-oxindole- 3-carboxamides wharein the N-substituent is thienyl, furyl, phenyl or substituted phenyl, are inhibitors of cycloxygenase and lipoxygenase enzymes and are useful as anti-inflammatory agents in mammals, (see fig.I) (I) (wherein R1 is thienyl, furyl or 2-thiazolyl; R is thienyl, furyl or Image [in which X is H, F, Cl, C1-4alkyl, C1-4alkoxy, C1-4alkylthio, nitro or CF3; and Y is H, F or Cl]; and R3 and R4 may be the same or different and are H, F, Cl, Br, C1-4alkyl, C1-4alkoxy, C1-4alkylthio nitro of CF3).

ertains hétéroaryloxindole-3-carboxamides substitués en N où le substituant en N est un groupe thiényle, furyle, phényle ou phényle substitué, sont des inhibiteurs des enzymes cycloxygénase et lipoxygénase et sont utiles comme agents anti-inflammatoires chez les mammifères (voir la fig. I) (I) (où R1 est un groupe thiényle, furyle ou 2-thiazolyle; R

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