Anti-inflammatory 17.beta.-carbothioate ester derivatives of...

C - Chemistry – Metallurgy – 07 – J

Patent

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C07J 31/00 (2006.01) A61K 31/56 (2006.01) A61P 5/44 (2006.01) A61P 11/06 (2006.01) A61P 17/00 (2006.01)

Patent

CA 2445839

There are provided compound of formula (I) wherein R1 represents C1-6 alkyl or C1-6 haloalkyl; R2 represents C3-8 cycloalkyl or C3-8 cycloalkenyl either of which may optionally be substituted by one or more groups selected from oxo, methyl, methylene and halogen; R3 represents hydrogen, methyl (which may be in either the .alpha. or .beta. configuration) or methylene; R4 and R5 are the same or different and each represents hydrogen or halogen; and (AA) represents a single or a double bond; and solvates thereof, processes for preparing them and their use in therapy.

L'invention porte sur un composé de la formule (I) dans laquelle R¿1? représente C¿1-6? alkyle ou C¿1-6? haloalkyle; R¿2? représente C¿3-8? cycloalkyle ou C¿3-8? cycloalcényle, l'un ou l'autre pouvant être éventuellement substitué par un ou plusieurs groupes sélectionnés parmi oxo, méthyle, méthylène et halogène; R¿3? représente hydrogène, méthyle (qui peut avoir la configuration .alpha. ou .beta.) ou méthylène; R¿4? et R¿5? sont identiques ou différents et représentent chacun hydrogène ou halogène; et (AA) représente une liaison simple ou double; et l'invention porte également sur des solvates de ce composé, sur leurs procédés de préparation et sur leur utilisation en thérapie.

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