Anti-inflammatory agents

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 487/08 (2006.01) A61K 31/439 (2006.01) A61K 31/55 (2006.01) A61P 11/06 (2006.01) A61P 17/02 (2006.01) A61P 17/06 (2006.01) A61P 19/02 (2006.01) A61P 19/10 (2006.01) A61P 25/28 (2006.01) A61P 29/00 (2006.01) A61P 31/12 (2006.01) A61P 37/00 (2006.01) C07D 453/06 (2006.01)

Patent

CA 2577274

The invention provides compounds, compositions, and uses of compounds of general formula (I) or pharmaceutically acceptable salts thereof, for the preparation of a medicament intended to treat an inflammatory disorder wherein y is any integer from 1 to 8; z is any integer from 1 to 8; with the proviso that y and z cannot both equal 1; X is -C -(Y)k-(R1)n or SO2-(Y)k (R1)n; k is 0 or 1; Y is a cycloalkyl or polycyloalkyl group (such as an adamantyl, adamantanemethyl, bicyclooctyl, cyclohexyl, cyclopropyl group); or Y is a cycloalkenyl or polycycloalkenyl group.

L'invention se rapporte à des composés, des compositions, et des utilisations de composés représentés par la formule (I) ou des sels pharmaceutiquement acceptables de ceux-ci, pour la préparation d'un médicament conçu pour traiter un trouble inflammatoire. Dans la formule (I) y est un chiffre entier compris entre 1 et 8; z est un chiffre entier compris entre 1 et 8; à condition que y et z ne soient pas tous les deux égaux à 1; X est -C -(Y)k-(R1)n ou SO2-(Y)k (R1)n; k est 0 ou 1; Y est un groupe cycloalkyle polycyloalkyle (par exemple un groupe adamantyle, adamantanemethyle, bicyclooctyle, cyclohexyle, cyclopropyle); ou Y est un groupe cycloalcenyle ou polycycloalcenyle.

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