Anti-inflammatory agents

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 211/76 (2006.01) A61K 31/395 (2006.01) A61K 31/4015 (2006.01) A61K 31/45 (2006.01) A61P 29/00 (2006.01) C07D 207/273 (2006.01) C07D 225/02 (2006.01)

Patent

CA 2612298

The invention provides compounds, pharmaceutical compositions and uses of compounds of general formula (I) or a pharmaceutically acceptable salt thereof, for the preparation of a medicament intended to treat an inflammatory disorder; wherein z is 1, 2 or 4; X is -CO-Yk-(R1)n or SO2-Yk-(R1)n; k is 0 or 1; Y is a cycloalkyl or polycyloalkyl group (such as an adamantyl, adamantanemethyl, bicyclooctyl, cyclohexyl, cyclopropyl group); or is a cycloalkenyl or polycycloalkenyl group; each R1 is independently selected from hydrogen or an alkyl, haloalkyl, alkoxy, haloalkoxy, alkenyl, alkynyl or alkylamino radical of 1 to 20 carbon atoms (for example of 5 to 20 carbon atoms, of 8 to 20 carbon atoms, of 9 to 20 carbon atoms, of 10 to 18 carbon atoms, of 12 to 18 carbon atoms, of 13 to 18 carbon atoms, of 14 to 18 carbon atoms, of 13 to 17 carbon atoms); or each R1 is independently selected from fluoro, chloro, bromo, iodo, hydroxy, oxyalkyl, amino, aminoalkyl or aminodialkyl radical; and n is any integer from 1 to m, where m is the maximum number of substitutions permissible on the cyclo-group Y (such that n=1 if k=0, such that the R1 group is bonded directly to the carbonyl or sulfonyl group); provided that simultaneously X cannot be an undec-10-en-l-oyl group and z be equal to 1 or 2; or alternatively R1 is selected from a peptido radical having from 1 to 4 peptidic moieties linked together by peptide bonds.

L'invention concerne des composés, des compositions pharmaceutiques et des utilisations des composés de la formule générale (I), ou un sel pharmaceutiquement acceptable de ces derniers, dans la préparation d'un médicament destiné à traiter un trouble inflammatoire, où z est 1, 2 ou 4; X est -CO-Yk-(R1)n ou SO2-Yk-(R1)n; k est 0 ou 1; Y est un groupe cycloalkyle ou polycyloalkyle (par exemple un groupe adamantyle, adamantaneméthyle, bicyclooctyle, cyclohexyle, cyclopropyle); ou est un groupe cycloalcényle ou polycycloalcényle; chaque R1 est choisi indépendamment entre l'hydrogène ou un radical alkyle, haloalkyle, alcoxy, haloalcoxy, alcényle, alkynyle ou alkylamino de 1 à 20 atomes de carbone (par exemple de 5 à 20 atomes de carbone, de 8 à 20 atomes de carbone, de 9 à 20 atomes de carbone, de 10 à 18 atomes de carbone, de 12 à 18 atomes de carbone, de 13 à 18 atomes de carbone, de 14 à 18 atomes de carbone, de 13 à 17 atomes de carbone); ou chaque R1 est choisi indépendamment entre un radical fluoro, chloro, bromo, iodo, hydroxy, oxyalkyle, amino, aminoalkyle ou aminodialkyle; et n est n'importe quel entier entre 1 et m, où m est le nombre maximum de substitutions permises sur le groupe cyclo Y (de telle manière que n=1 si k=0, de telle manière que le groupe R1 est lié directement au groupe carbonyle ou sulfonyle); à condition que simultanément X ne soit pas un groupe undec-10-en-l-oyle et que z soit égal à 1 ou 2; ou, dans un autre mode de réalisation, R1 est choisi parmi un radical peptido renfermant de 1 à 4 fragments peptidiques reliés entre eux par des liaisons peptide.

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