Anti-inflammatory agents

Details Anti-inflammatory agents Anti-inflammatory agents

A - Human Necessities

61

K

A61K 31/215 (2006.01) A61K 31/216 (2006.01) A61K 31/22 (2006.01) A61K 31/223 (2006.01) A61K 31/34 (2006.01) A61K 31/341 (2006.01) A61K 31/38 (2006.01) A61K 31/381 (2006.01) A61K 31/44 (2006.01) A61K 31/4406 (2006.01) A61K 31/445 (2006.01)

Patent

CA 2320285

Compounds of general formula (I) wherein R4 is an ester or thioester group and R, R1, R2, and R3 are as specified in the description, inhibit intracellular Leukotriene A4 hydrolase activity and are therefore of value for the treatment of inflammatory disease.

L'invention porte sur des composés de la formule générale (I) dans laquelle R¿4? représente un groupe ester ou thioester et R, R¿1?, R¿2? et R¿3? sont tels que décrits dans la demande. Ces composés inhibent l'activité intracellulaire de l'hydrolase Leucotriène A¿4 et sont par conséquent utiles dans le traitement des maladies inflammatoires.

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