A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/496 (2006.01) A61P 27/00 (2006.01) A61P 29/00 (2006.01) C07D 211/90 (2006.01)
Patent
CA 2360689
Anti-inflammatory agents and inhibitors against increase in ocular tension caused by irradiation with lasers, containing as the active ingredient 1,4- dihydropyridine derivatives represented by general formula (I) or acid addition salts thereof wherein X1 and X2 are each independently hydrogen, fluoromethyl, fluoromethoxy, halogeno, cyano, or nitro; R1 is lower alkyl; R2 is acyl, alkoxycarbonyl, acylalkyl, N-alkylated carbamoylalkyl, alkoxyalkyl, alkoxycarbonylalkyl, acyloxyalkyl, nitratoalkyl, cyanoalkyl, heterocycle- bearing alkyl, haloalkyl, alkenyl, or alkynyl; A is alkylene bearing a carbon atom which two alkyl groups are bonded to and having 5 or more carbon atoms in total; and m is an integer of 1 to 3.
L'invention concerne des agents anti-inflammatoires et des inhibiteurs réduisant l'augmentation de la tension oculaire provoquée par une irradiation par laser, qui contiennent comme principe actif des dérivés de 1,4-dihydropyridine représentés par la formule générale (I) ou des sels d'addition d'acide de ceux-ci. Dans la formule, X?1¿ et X?2¿ sont chacun indépendamment hydrogène, fluorométhyle, fluorométhoxy, halogéno, cyano ou nitro ; R?1¿ est alkyle inférieur ; R?2¿ est acyle, alcoxycarbonyle, acylalkyle, carbamoylalkyle N-alkylé, alcoxyalkyle, alcoxycarbonylalkyle, acyloxyalkyle, nitratoalkyle, cyanoalkyle, alkyle hétérocyclique, haloalkyle, alcényle ou alcynyle ; A est un alkylène comportant un atome de carbone auquel sont liés deux groupes alkyle, et doté de 5 ou davantage d'atomes de carbone au total ; et m est un nombre entier compris entre 1 et 3.
Fetherstonhaugh & Co.
Kyoto Pharmaceutical Industries Ltd.
Senju Pharmaceutical Co. Ltd.
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