Anti-inflammatory aminophenol derivatives

Details Anti-inflammatory aminophenol derivatives Anti-inflammatory aminophenol derivatives

C - Chemistry, Metallurgy

07

D

167/208, 260/263

C07D 231/38 (2006.01) A61K 31/395 (2006.01) C07D 213/82 (2006.01) C07D 215/38 (2006.01) C07D 231/06 (2006.01) C07D 233/88 (2006.01) C07D 235/30 (2006.01) C07D 237/20 (2006.01) C07D 237/22 (2006.01) C07D 239/42 (2006.01) C07D 239/48 (2006.01) C07D 241/20 (2006.01) C07D 249/04 (2006.01) C07D 249/14 (2006.01) C07D 253/07 (2006.01) C07D 261/14 (2006.01) C07D 263/48 (2006.01) C07D 285/08 (2006.01) C07D 285/135 (2006.01) C07D 311/92 (2006.01) C07D 333/36 (2006.01) C07D 333/38 (2006.01) C07D 401/12 (2006.01) C07D

Patent

CA 2017169

ABSTRACT Anti-inflammatory aminophenol derivatives There are disclosed compounds of formula I: Image in which R1 represents C(O)YZ or SO2R10, Y represents a single bond, O, NR11 or CO, z represents hydrogen, alkyl or alkyl substituted by one or more substituents selected from hydroxy, alkoxy, acyloxy, carboxy, alkoxycarbonyl, CONR12R13, arylalkoxy, Ar1, heterocycle, halo, cyano or NR14R15, R2, R3, R5 and R6, which may be the same or different, represent hydrogen, alkyl, alkoxy or halogen, R4 and R11, which may be the same or different, represent hydrogen or alkyl, R10 represents alkyl, X represents a heterocycle optionally substituted by one or more substituents selected from alkyl, cycloalkyl, alkoxy, alkoxycarbonyl, carboxy, hydroxyalkyl, halo, CONR16R17, NR18R19, or Ar2, Ar1 and Ar2 which may be the same or different represent aryl or aryl substituted by one or more substituents selected from halogen, nitro, alkoxy, carboxy, alkyl or trihaloalkyl, R12, R13, R14, R15, R16, R17, R18 and R19, which may be the same or different, represent hydrogen, alkyl or benzyloxycarbonyl, or a pharmaceutically acceptable N-oxide, N-alkyl, salt, ester or amide derivative thereof, for use as a pharmaceutical, eg an anti-inflammaory agent.

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