Anti-inflammatory, analgesic, and antipyretic pharmaceutical...

Details Anti-inflammatory, analgesic, and antipyretic pharmaceutical... Anti-inflammatory, analgesic, and antipyretic pharmaceutical...

A - Human Necessities

61

K

167/246

A61K 31/275 (2006.01) A61K 31/12 (2006.01) A61K 31/19 (2006.01) A61K 31/215 (2006.01) C07C 49/248 (2006.01) C07C 49/747 (2006.01) C07C 49/753 (2006.01) C07C 49/835 (2006.01) C07C 59/52 (2006.01) C07C 59/90 (2006.01)

Patent

CA 1167767

ABSTRACT OF THE DISCLOSURE A new anti-inflammatory, analgesic, and antipyretic pharmaceutical composition is disclosed which contains a 3,5-di-tert-butyl-4-hydroxystyrene derivative of the formula: Image wherein R1 stands for a group represented by COR3 [R3 denotes a group of OR4 (R4 is a hydrogen atom or an alkyl group with C1 ~ C4), an alkyl group with C1 ~ C3, a phenyl group, or an amino group], a nitro group, or an alkylsulfonyl group represented by SO2R5 (R5 is an alkyl group with C1 ~ C3); and R2 stands for a hydrogen atom, an alkyl group with C1 ~ C4, a hydroxyalkyl group with C1 ~ C4, a cyano group, or an acyl group represented by COR6 (R6 is an alkyl group with C1 ~ C3), or its pharmaceutically acceptable salt as an active ingredient in association with pharmaceutical excipients. The pharmaceutical composition has excellent anti- inflammatory, analgesic, and antipyretic activities and low toxicity.

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