C - Chemistry – Metallurgy – 07 – J
Patent
C - Chemistry, Metallurgy
07
J
260/21, 260/59
C07J 1/00 (2006.01) C07J 5/00 (2006.01) C07J 21/00 (2006.01)
Patent
CA 1274502
ANTI-INFLAMMATORY CARBOXY PREGNANE DERIVATIVES ABSTRACT OF THE DISCLOSURE Compounds of the formula: Image wherein one X is COOR, CH2COOR, CH(COOR)2, CONHR, CH2CONHR, or CN remaining X's are H, F, CH3, OH, COOR, CH2COOR, CH(COOR)2, CONHR, CH2CONHR, or CN, Y is Image R is H, alkyl of 1-5 carbon atoms, or benzyl; R1 is CH2OR3, COOR, or CONHR; R2 is H, OR3, or Br; R3 is H, COR4, or tetrahydropyranyl; R4 is alkyl of 1-5 carbon atoms or benzyl; R5 is H or COR4; ? represents a single or double bond; ? represents .alpha.-position, .beta.-position, or a mixture of .alpha.- and .beta.-positions; and ? represents .alpha.-position; and methods for preparing the same. Image R is H, alkyl of 1-5 carbon atoms, or benzyl; Rl is CH20R3, COOR, or CONHR; R2 is H, OR3, or Br; R3 is H, COR4, or tetrahydropyranyl; R4 is alkyl of 1-5 carbon atoms or benzyl; R5 is H or COR4; ___ represents a single or double bond; ~v represents -position, g-position, or a mixture of - and B-positions; and --- represents ~-position; and methods for preparing the same.
530482
Macrae & Co.
Research Corporation Technologies Inc.
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