Anti-inflammatory compounds and uses thereof

Details Anti-inflammatory compounds and uses thereof Anti-inflammatory compounds and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/08 (2006.01) A61K 38/16 (2006.01) A61P 29/00 (2006.01) C07K 7/06 (2006.01) C07K 14/47 (2006.01) C12N 9/12 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2414290

The present invention provides anti-inflammatory compounds, comprising at least one NEMO binding domain, pharmaceutical compositions thereof, and methods of use thereof for treating inflammatory disorders. The present invention also provides methods of identifying anti-inflammatory compounds and methods of inhibiting NF-.kappa.B-dependent target gene expression in a cell.

L'invention concerne des composés anti-inflammatoires, des compositions pharmaceutiques de ces derniers, et leurs procédés d'utilisation pour traiter des troubles inflammatoires. L'invention concerne également des procédés d'identification de composés anti-inflammatoires ainsi que des procédés d'inhibition de l'expression de gène cible dépendant de NF-.kappa.B dans une cellule.

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