C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 15/24 (2006.01) A61K 31/704 (2006.01) A61P 29/00 (2006.01) C07C 13/48 (2006.01) C07C 39/17 (2006.01) C07C 49/737 (2006.01) C07C 49/753 (2006.01) C07C 50/14 (2006.01) C07C 50/32 (2006.01) C07C 69/14 (2006.01) C07H 15/203 (2006.01)
Patent
CA 2430398
Methods for treating, preventing, or inhibiting diseases and disorders associated with inflammation, cell-proliferation, and pain comprising the administration of a compound having the structural formula (I) wherein R1 is a hydrogen, alkyl, aryl, hydroxyalkyl, cycloalkyl, cycloalkenyl, carboxylic acid, alkylamino or amide group having from 2 to 20 carbon atoms, R2, R3, and R4 are each independently hydrogen or an acyl residue having from 1 to 6 carbon atoms, R5 is hydrogen, CH3, or CH2OH, and R6 is an organo group such as a hydrocarbon having from 1 to 10 carbon atoms are disclosed. Other seco- pseudopterosins and compounds related to pseudopterosins are disclosed.
L'invention concerne des procédés de traitement ou d'inhibition de maladies ou pathologies associées à l'inflammation, à la prolifération cellulaire et à la douleur, ces procédés consistant à administrer un composé possédant la formule développée (I) dans laquelle R¿1? représente hydrogène, alkyle, hydroxyalkyle, cycloalkyle, cycloalcényle, acide carboxylique, alkylamino ou un groupe amide possédant 2 à 20 atomes de carbone, R¿2?, R¿3?, et R¿4? représentent chacun indépendamment hydrogène ou un reste acyle possédant 1 à 6 atomes de carbone, R¿5? représente hydrogène, CH¿3?, ou CH¿2?OH, et R¿6? représente un groupe organo tel qu'un hydrocarbure possédant 1 à 10 atomes de carbone. L'invention concerne également d'autres séco-pseudoptérosines ainsi que des composés associés aux pseudoptérosines.
Jacobs Robert S.
Kerr Russell G.
Florida Atlantic University Board Of Trustees
Ridout & Maybee Llp
The Regents Of The University Of California
LandOfFree
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