Anti-inflammatory indole derivatives

Details Anti-inflammatory indole derivatives Anti-inflammatory indole derivatives

C - Chemistry, Metallurgy

07

D

C07D 209/42 (2006.01) A61K 31/40 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01)

Patent

CA 2357013

Compounds of formula (I) or a pharmaceutically acceptable salt,in vivo hydrolysable ester, or amide thereof, where X is CH2 or SO2; R1 is an optionally substituted aryl or heteroaryl ring; R4 is a group OR15 or S(O)qR15, where q is 0, 1 or 2 and R15 is a substituted hydrogen-containing alkyl group; and R2, R3, R5, R6 and R7 are specified organic groups. These compounds are useful in therapy, in particular of inflammatory disease, and methods of producing them as well as pharmaceutical compositions containing them are also described and claimed.

La présente invention concerne des composés de formule (I) ou d'un sel acceptable sur le plan pharmaceutique, d'un ester s'hydrolysant in vivo, ou d'un amide de ces composés. Dans cette formule X est un groupe CH¿2? ou SO¿2?, R?1¿ est un cycle aryle ou hétéroaryle éventuellement substitué, R?4¿ est un groupe OR?15¿ ou S(O)¿q?R?15¿, où q vaut 0, 1 ou 2 et R?15¿ est un groupe alkyle contenant un hydrogène substitué, et R?2¿, R?3¿, R?5¿, R?6¿ et R?7¿ sont des groupes organiques spécifiés. Ces composés sont utiles en thérapie, en particulier de maladie inflammatoire. L'invention concerne aussi des procédés de production de ces composés ainsi que des compositions les contenant.

Affiliated with

Also associated with

Rating

Anti-inflammatory indole derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Anti-inflammatory indole derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Anti-inflammatory indole derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1345172