Anti-inflammatory medicaments

Details Anti-inflammatory medicaments Anti-inflammatory medicaments

C - Chemistry, Metallurgy

07

D

C07D 231/40 (2006.01) A61K 31/4155 (2006.01) A61K 31/4196 (2006.01) A61K 31/422 (2006.01) A61K 31/433 (2006.01) A61K 31/5377 (2006.01) C07D 249/12 (2006.01) C07D 263/06 (2006.01) C07D 285/06 (2006.01) C07D 413/10 (2006.01)

Patent

CA 2592116

Novel compounds and methods of using those compounds for the treatment of inflammatory conditions, hyperproliferative diseases, cancer, and diseases characterized by hyper-vascularization are provided. ][n a preferred embodiment, modulation of the activation state of p38 kinase protein, abl kinase protein, bcr-abl kinase protein, braf kinase protein, VEGFR kinase protein, or PDGFR kinase protein comprises the step of contacting said kinase protein with the novel compounds.

Cette invention concerne de nouveaux composés et des procédés d'utilisation de ces composés dans le traitement des états inflammatoires, des maladies hyperprolifératives, des cancers et des maladies se caractérisant par une hypervascularisation. Dans un mode de réalisation préféré, la modulation de l'état d'activation de la protéine kinase p38, de la protéine kinase abl, de la protéine kinase bcr-abl, de la protéine kinase braf, de la protéine kinase VEGFR ou de la protéine kinase, PDGFR consiste à mettre en contact cette protéine kinase avec ces nouveaux composés.

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