Anti-inflammatory quinic acid derivatives for oral...

Details Anti-inflammatory quinic acid derivatives for oral... Anti-inflammatory quinic acid derivatives for oral...

C - Chemistry, Metallurgy

07

C

C07C 235/40 (2006.01) A61K 31/16 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2713394

Disclosed are compounds comprising analogs of quinic acids or shikimic acids having anti-inflammatory properties. The compounds are suitable for oral administration, stable, and demonstrate significant efficacy in inhibiting NF-kB, inhibiting leukocyte adhesion, and inhibiting other factors and cytokines known to be involved in inflammatory disease.

L'invention concerne des composés comprenant des analogues d'acides quiniques ou d'acides shikimiques qui possèdent des propriétés anti-inflammatoires. Ces composés sont adaptés à l'administration par voie orale, sont stables et présentent une efficacité significative en ce qui concerne l'inhibition du NF-kB, l'inhibition de l'adhérence leucocytaire et l'inhibition d'autres facteurs et cytokines connus pour être impliqués dans une maladie inflammatoire.

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