C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 7/06 (2006.01) A61K 38/08 (2006.01) A61K 38/16 (2006.01) A61K 39/35 (2006.01) C07K 14/235 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2145881
The present invention is directed to methods of supressing inflammatory responses, inducing tolerance to an antigen, and suppressing cell adhesion, e.g., involved in metastasis, by the administration of lectin derived carbohydrate binding peptides or derivatives thereof, in particular, peptides capable of binding terminally linked .alpha.-sialic acid(2->6).beta.Gal-and/or .alpha.-sialic acid (2->3).beta.3Gal- groups on structures or molecules comprising such groups. Pharmaceutical compositions containing such lectin derived carbohydrate binding peptides or derivatives thereof are also disclosed.
La présente invention se rapporte à des procédés de suppression de réponses inflammatoires, d'induction de tolérance à un antigène et de suppression de l'adhésion cellulaire, par exemple celle impliquée dans les métastases, par l'administration de peptides de fixation de glucide dérivés de lectine, ou de dérivés de ces derniers, en particulier des peptides pouvant fixer des groupes acide alpha-sialique (2->6)alphaGal- et/ou acide alpha-sialique (2->3)alphaGal- à liasion terminale sur des structures ou des molécules comprenant de tels groupes. Des compositions pharmaceutiques contenant de tels peptides de fixation de glucide de carbone dérivés de lectine, ou des dérivés de ces peptides, sont également décrites.
Armstrong Glen D.
Heerze Louis D.
Smith Richard
Alberta Research Council Inc.
Torys Llp
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