A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/16 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2211563
The present invention is directed to methods of supressing inflammatory responses, inducing tolerance to an antigen, and suppressing cell adhesion e.g., involved in metastasis, by the administration of lectin derived carbohydrate binding peptides or derivatives thereof, in particular, peptides capable of binding terminally linked .alpha.-sialic acid(2->6).beta.Gal-and/or .alpha.-sialic acid (2 -> 3).beta.Gal- groups on structures or molecules comprising such groups. Pharmaceutical compositions containing such lectin derived carbohydrate binding peptides or derivatives thereof are also disclosed.
Le présent brevet divulgue des méthodes pour la suppression de réactions inflammatoires, l'induction de la tolérance à un antigène, et la suppression de l'adhésion cellulaire, par exemple, dans le cas de métastases, par l'administration de peptides liant des glucides dérivés des lectines ou des dérivés de ceux-ci, en particulier, des peptides pouvant lier des groupements terminaux acide alpha sialique (2->6). beta. Gal- et (ou) acide alpha sialique (2->3).beta. Gal- sur des structures ou des molécules portant ces groupements. Des compositions pharmaceutiques renfermant ces peptides liant des glucides dérivés des lectines ou des dérivés de ceux-ci sont également divulguées.
Armstrong Glen
Heerze Louis D.
Smith Richard
Alberta Research Council
Alberta Research Council Inc.
Torys Llp
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