Anti-inflammatory, tolerogenic and immunostimulatory...

A - Human Necessities – 61 – K

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A61K 39/39 (2006.01) A61K 38/16 (2006.01) A61K 38/43 (2006.01) A61K 38/46 (2006.01) A61K 38/47 (2006.01) C07K 14/235 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2144850

The present invention is directed to methods of suppressing inflammatory responses, inducing tolerance to an antigen, sti- mulating immune response to antigens, and suppressing or enhancing cell adhesion, e.g., involved in metastasis, by the adminis- tration of carbohydrate binding proteins or fragments or derivatives thereof, in particular, proteins capable of binding .alpha.-2,6 sialic acid structures and/or .alpha.2,3 sialic acid structures. Pharmaceuticcal compositions containing such .alpha.-2,6 sialic acid and .alpha.-2,6 sialic acid binding proteins or fragments or derivates thereof are also disclosed.

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