Anti-influenza compounds

Details Anti-influenza compounds Anti-influenza compounds

C - Chemistry, Metallurgy

07

D

C07D 239/46 (2006.01) A61K 31/13 (2006.01) A61K 31/215 (2006.01) A61K 31/351 (2006.01) A61K 31/505 (2006.01) A61K 31/506 (2006.01) A61K 31/675 (2006.01) A61P 31/16 (2006.01) C07D 403/12 (2006.01) C07F 9/6512 (2006.01)

Patent

CA 2713848

The present invention provides pyrimidinyl compounds of formula (I) and pharmaceutically acceptable salts thereof. These compounds may be used for the inhibition of influenza. In particular, the compounds of the invention may be used for the treatment or prophylaxis of influenza A, most particularly H1N1 or H5N1 influenza. The compounds of the invention can also be used for the treatment or prophylaxis of a disease caused by Vibrio cholerae, Clostridium perfringens, Streptococcus pneumoniae, Arthrobacter sialophilus, an orthomyxovirus, a paramyxovirus, a parainfluenza virus, mumps virus, Newcastle disease virus, fowl plague virus or Sendai virus.

La présente invention porte sur des composés pyrimidinylés de formule (I) et sur des sels pharmaceutiquement acceptables de ces composés. Ceux-ci peuvent être utilisés pour l'inhibition de la grippe. En particulier, les composés de l'invention peuvent être utilisés pour le traitement ou la prophylaxie de la grippe A, plus particulièrement de la grippe H1N1 ou H5N1. Les composés de l'invention peuvent également être utilisés pour le traitement ou la prophylaxie d'une maladie provoquée par Vibrio cholerae, Clostridium perfringens, Streptococcus pneumoniae, Arthrobacter sialophilus ou un orthomyxovirus, un paramyxovirus, un virus parainfluenza, le virus des oreillons, le virus de la maladie de Newcastle, le virus de la grippe aviaire ou le virus Sendai.

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