Anti-insomnia compositions and methods

Details Anti-insomnia compositions and methods Anti-insomnia compositions and methods

A - Human Necessities

61

K

A61K 31/437 (2006.01) A61K 9/12 (2006.01) A61P 25/20 (2006.01)

Patent

CA 2687085

Compositions of Zolpidem, and methods for their manufacture and use for treating insomnia. The compositions are formulated as oral sprays for transmucosal absorption of Zolpidem. The methods of treatment in some cases involve night-time dosing administration to achieve therapeutic Zolpidem blood levels within 20 minutes or less, tapering off to less than 20 ng/ml within less than five hours, in some cases less than four hours, post dosing.

L'invention concerne des compositions de Zolpidem et des procédés pour leur fabrication et leur utilisation dans le traitement de l'insomnie. Les compositions sont formulées en tant que pulvérisateurs oraux pour une absorption transmucosale du Zolpidem. Les procédés de traitement impliquent dans certains cas une administration nocturne dosée pour atteindre des concentrations thérapeutiques de Zolpidem dans le sang en 20 minutes ou moins, la diminution jusqu'à moins de 20 ng/ml dans un délai inférieur à cinq heures, dans certains cas inférieur à quatre heures, après le dosage.

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