C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61P 37/06 (2006.01) C07K 16/24 (2006.01) C12N 5/20 (2006.01) G01N 33/564 (2006.01) G01N 33/577 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2437161
The present invention relates generally to the generation and characterization of neutralizing anti-IFN-.alpha. monoclonal antibodies with broad reactivity against various IFN-.alpha. subtypes. The invention further relates to the use of such anti-IFN-.alpha. antibodies in the diagnosis and treatment of disorders associated with increased expression of IFN-.alpha., in particular, autoimmune disorders such as insulin-dependent diabetes mellitus (IDDM) and systemic lupus erythematosus (SLE).
La présente invention concerne d'une façon générale la génération et la caractérisation d'anticorps monoclonaux anti-IFN-.alpha. neutralisants qui possèdent une grande réactivité contre divers sous types de IFN-.alpha.. Cette invention concerne aussi l'utilisation de ces anticorps anti-IFN dans le diagnostic et le traitement de troubles associés à une augmentation de l'expression de IFN-.alpha., en particulier les troubles autoimmuns tels que le diabète insulino-dépendant (DID) et que le lupus érythémateux disséminé.
Chuntarapai Anan
Kim Jin K.
Presta Leonard G.
Stewart Timothy
Dennison Associates
Genentech Inc.
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