Anti-ip-10 antibodies and methods of use thereof

Details Anti-ip-10 antibodies and methods of use thereof Anti-ip-10 antibodies and methods of use thereof

C - Chemistry, Metallurgy

07

K

C07K 16/24 (2006.01) A61P 37/06 (2006.01)

Patent

CA 2678626

The invention relates to fully human antibodies, and fragments thereof, that bind to interferon-inducible-protein-10 (IP-IO, CXCLlO), thereby modulating the interaction between IP-IO and its receptor, CXCR3, and/or modulating the biological activities of IP-IO. The invention also relates to the use of such anti-IP- 10 antibodies in the prevention or treatment of immune-related disorders and in the amelioration of one or more symptoms associated with an immune-related disorder.

L'invention concerne des anticorps totalement humains et des fragments de ceux-ci, qui se lient à la protéine 10 inductible par un interféron (IP-I0, CXCL10), modulant ainsi l'interaction entre IP-I0 et son récepteur, CXCR3 et/ou modulant les activités biologiques de IP-IO). L'invention concerne également l'utilisation de tels anticorps anti-IP10 dans la prévention ou le traitement de troubles de nature immunitaire et dans l'amélioration d'un ou plusieurs symptômes associés à un trouble de nature immunitaire.

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