Anti-itching agent

Details Anti-itching agent Anti-itching agent

A - Human Necessities

61

K

A61K 31/485 (2006.01) A61P 17/04 (2006.01) C07D 489/00 (2006.01) C07D 489/08 (2006.01)

Patent

CA 2561509

A novel anti-itching agent useful for the treatment of itches accompanying various diseases. The anti-itching agent contains as an active ingredient a morphinan derivative having a specific nitrogenous cyclic substituent or a pharmacologically acceptable acid addition salt thereof, such as, e.g., N-(17- cyclopropylmethyl-4,5.alpha.-epoxy-3,14-dihydroxymorphinan-6.beta.- yl)phthalimide hydrochloride, [Chemical formula 1] (1) or N-(17- cyclopropylmethyl-4,5.alpha.-epoxy-3,14-dihydroxy~morphinan-6.beta.-yl)- 3,4,5,6-tetrahydrophthalimide tartrate.

Un agent anti prurit novateur utile pour le traitement des prurits accompagnant diverses maladies. L'agent anti prurit contient en tant qu'ingrédient actif un dérivé de morphine comportant un substituant cyclique azoté spécifique ou un sel d'addition acide de celui-ci pouvant être accepté en termes pharmaceutiques tel que, par exemple, un chlorhydrate de N-(17-cyclopropylméthyl-4,5.alpha.-époxy-3,14-dihydroxymorphine-6.beta.-yl) phthalimide, [Formule chimique 1] (1) ou un tartrate de N-(17-cyclopropylméthyl-4,5.alpha.-époxy-3,14-dihydroxy­morphine-6.beta.-yl)-3,4,5,6-tétrahydrophthalimide.

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