Anti-kir antibodies, formulations, and uses thereof

Details Anti-kir antibodies, formulations, and uses thereof Anti-kir antibodies, formulations, and uses thereof

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61P 35/00 (2006.01) C07K 16/28 (2006.01)

Patent

CA 2675291

A novel lgG4 isotype anti-KIR antibody, novel formulations of this and other lgG4 anti-KIR antibodies, and methods of using such formulations are provided. Also described are compositions, formulations, dosages, and administration regimens suitable for NK cell activation and therapeutic applications of anti-KIR antibodies, as well as kits comprising one or more anti-KIR antibodies with instructions for use in treating cancer.

L'invention porte sur un nouvel anticorps anti-KIR isotype IgG4, sur de nouvelles formulations de celui-ci et d'autres anticorps anti-KIR IgG4, et sur des procédés d'utilisation de telles formulations. L'invention porte également sur des compositions, des formulations, des dosages et des régimes d'administration appropriés pour une activation des lymphocytes NK et des applications thérapeutiques d'anticorps anti-KIR, ainsi que sur des coffrets comprenant un ou plusieurs anticorps anti-KIR avec des instructions pour une utilisation dans le traitement du cancer.

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