Anti-leukemic .beta.-glycosyl c-nucleosides

Details Anti-leukemic .beta.-glycosyl c-nucleosides Anti-leukemic .beta.-glycosyl c-nucleosides

C - Chemistry, Metallurgy

07

H

260/228

C07H 7/06 (2006.01) C07D 487/04 (2006.01) C07D 491/04 (2006.01) C07D 493/04 (2006.01) C07D 495/04 (2006.01)

Patent

CA 1224460

ABSTRACT OF THE DISCLOSURE Beta-glycosyl C-nucleoside compound of the formula Image wherein X is NR10, S or O R10 is H or alkyl with 1 to 6 carbon atoms Image wherein R6, R7 and R8 are independently selected from H or alkyl of 1 to 6 carbon atoms; or R2 is H, NH2, Image , SR12, or OR12 wherein R16, R11 and R12 are independently selected from H or alkyl of 1-6 carbon atoms; R3 is OH, SR13, or OR9; R4 is OH, SR14 or OR15; R9, R13, R14 and R15 are individually selected from C1-C6 alkyl and C1 to C6 acyl; R5 is OH or H, R'5 is OH or H with the proviso that at least one of R5 or R'5 is H; excluding 2-deazaoxoformycin, and HCl salts thereof. A method of forming the beta-glycosyl C- nucleoside compounds is also disclosed. These compounds have been found to inhibit the growth of leukemic cells. They have anti-tumor activity and also have some anti-viral activity.

408495

Affiliated with

Also associated with

Rating

Anti-leukemic .beta.-glycosyl c-nucleosides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Anti-leukemic .beta.-glycosyl c-nucleosides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Anti-leukemic .beta.-glycosyl c-nucleosides will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1329400