Anti-lewis y anti-idiotypic antibodies and uses thereof

Details Anti-lewis y anti-idiotypic antibodies and uses thereof Anti-lewis y anti-idiotypic antibodies and uses thereof

C - Chemistry, Metallurgy

07

K

C07K 16/42 (2006.01) C07K 16/28 (2006.01)

Patent

CA 2535804

This invention provides anti-idiotype antibodies specific for Anti-Lewis Y monoclonal antibodies. The present invention also directed against an ELISA screening method of mAbs produced by hybridoma clones for specific binding to the variable regions of hu3S193 and the ability of the anti-idiotypic mAB to inhibit hu3S193 binding to Lewis Y antigen. Additionally, the present invention provides a hybridoma capable of producing an anti-idiotype antibody specific for anti-Lewis Y monoclonal antibody. A further aspect of the invention is to provide a hybridoma, which is specific for anti-Lewis Y monoclonal antibody selected from the group consisting of LMH-1, LMH-2, LMH-3, or LMH-4. The present invention is also directed against a method to detect HAMA, HACA and HAHA responses using the antibody of the invention.

L'invention des anticorps anti-idiotype spécifiques des anticorps monoclonaux (mAB) anti-Lewis Y. L'invention concerne également un procédé de criblage ELISA de mAbs produits par des clones d'hybridome destinés à une liaison spécifique aux régions variables de hu3S193 et la capacité du mAB anti-idiotypique d'inhiber la liaison de hu3S193 à l'antigène Lewis Y. De plus, l'invention concerne un hybridome capable de produire un anticorps anti-idiotype spécifique pour l'anticorps monoclonal anti-Lewis Y. Un autre mode de réalisation de l'invention concerne un hybridome, spécifique pour un anticorps monoclonal anti-Lewis Y sélectionné dans le groupe comprenant LMH-1, LMH-2, LMH-3 ou LMH-4. L'invention concerne également un procédé de détection des réponses de HAMA, HACA et HAHA au moyen de l'anticorps selon l'invention.

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