C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 307/33 (2006.01) A61K 36/53 (2006.01) A61P 33/06 (2006.01)
Patent
CA 2624750
The present invention provides a novel antimalarial compound 3-[2-(2- Hydroxymethyl- 1, 4a, 5-trimethyl-7-oxo-l,2,3,4,4a, 7 8, 8a- octahydronaphthalen-l-yl)-ethyl]-5H-furan- 2-one of the formula (I) given below or pharmaceutically acceptable derivatives thereof, isolated from Gomphostema niveum and also provides a method for the extraction thereof as well as methods for the treatment of malaria using said compound.
La présente invention concerne un nouveau composé antipaludique 3-[2-(2-hydroxyméthyl-1, 4a, 5-triméthyl-7-oxo-l,2,3,4,4a, 7 8, 8a-octahydronaphthalène-l-yl)-éthyl]-5H-furan-2-one de formule (I) mentionnée ci-dessous ou des dérivés associés acceptables pharmaceutiquement isolés de Gomphostema niveum. Cette invention a aussi pour objet un procédé d'extraction associé, ainsi que des méthodes de traitement du paludisme à l'aide dudit composé.
Acharya Badri Narayan
Kaushik Mahabir Prashad
Nivsarkar Manisha
Prasanna Subramaniam
Sekhar Krishnamurthy
Borden Ladner Gervais Llp
The Director General Defence Research And Development Organisation
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