C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01) C12N 5/16 (2006.01) C12P 21/08 (2006.01)
Patent
CA 2600505
This invention relates to the use of monoclonal and polyclonal antibodies that specifically bind to and become internalized by mesothelin-positive cells and also induce an immune effector activity such as antibody dependent cellular cytotoxicity. The antibodies are useful in specific delivery of pharmacologic agents to mesotlielin expressing cells as well as eliciting an immune- effector activity particularly on tumor cells and precursors. The invention is also related to cells expressing the monoclonal antibodies, polyclonal antibodies, antibody derivatives, such as human, humanized, and chimeric monoclonal antibodies, antibody fragments, mammalian cells expressing the monoclonal antibodies, derivatives and fragments, and methods of treating cancer using the antibodies, derivatives and fragments.
L'invention concerne l'utilisation d'anticorps monoclonaux et polyclonaux qui se lient spécifiquement aux cellules exprimant ou portant la mésothéline et sont internalisées par celles-ci, et induisent aussi une activité d'effecteur immunitaire telle que la cytotoxicité cellulaire dépendant des anticorps. Les anticorps sont utiles dans l'apport spécifique d'agents pharmacologiques à des cellules exprimant la mésothéline, et aussi pour déclencher une activité d'effecteur immunitaire, en particulier sur des cellules tumorales et leurs précurseurs. L'invention concerne aussi des cellules exprimant ces anticorps monoclonaux, anticorps polyclonaux, dérivés d'anticorps tels que des anticorps monoclonaux humains, humanisés, chimères, des fragments d'anticorps, des cellules de mammifère exprimant ces anticorps monoclonaux, leurs dérivés et fragments, et des méthodes de traitement du cancer utilisant lesdits anticorps, dérivés et fragments.
Ebel Wolfgang
Grasso Luigi
Nicolaides Nicholas C.
Routhier Eric
Sass Philip M.
Gowling Lafleur Henderson Llp
Morphotek Inc.
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