Anti-mesothelin antibodies useful for immunological assays

Details Anti-mesothelin antibodies useful for immunological assays Anti-mesothelin antibodies useful for immunological assays

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01) C07K 19/00 (2006.01) C12N 15/62 (2006.01) C12N 15/63 (2006.01) G01N 33/569 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2607305

The present invention provides antibodies that have a surprisingly good combination of affinity for mesothelin and ability to be used in immunological assays for detecting the presence of mesothelin in biological samples. The invention further provides methods of using the antibodies, and kits comprising them. The antibodies can also be used to target toxins and other agents to cells expressing mesothelin, and can be used in methods and medicaments for inhibiting the growth of such cells.

L'invention concerne des anticorps qui présentent une combinaison étonnamment bonne d'affinité pour la mésothéline et la capacité d'être utilisés dans des dosages immunologiques afin de détecter la présence de la mésothéline dans des échantillons biologiques. L'invention concerne également des méthodes permettant d'utiliser les anticorps ainsi que les trousses comprenant les anticorps. Les anticorps selon l'invention peuvent également être utilisés pour cibler des toxines et d'autres agents sur des cellules exprimant la mésothéline et peuvent être utilisés dans des procédés et des médicaments afin d'inhiber la croissance de ces cellules.

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