Anti-microbial targeting chimeric pharmaceutical

A - Human Necessities – 61 – K

Patent

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Details

A61K 39/40 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) C07K 16/00 (2006.01) C07K 16/12 (2006.01) C12P 21/08 (2006.01)

Patent

CA 2452421

The present invention is based on the discovery of a composition that provides targeted anti-microbial effect. Specifically the composition contains a targeting moiety which recognizes a target microbial organism and an anti- microbial peptide moiety which has anti-microbial activity. In addition, the present invention provides methods of treating a microbial infection, e.g., on mucosal surfaces by using the compositions provided by the present invention.

L'invention concerne une composition ayant une activité antimicrobienne ciblée. Plus particulièrement, la composition de l'invention contient un fragment de ciblage qui identifie un organisme microbien cible et un fragment peptidique antimicrobien ayant une activité antimicrobienne. L'invention concerne en outre des méthodes de traitement d'une infection microbienne, par exemple sur des surfaces de muqueuses, qui mettent en oeuvre les compositions de l'invention.

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