C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/18 (2006.01) C07K 16/18 (2006.01) G01N 33/577 (2006.01)
Patent
CA 2141025
An IgM class monoclonal antibody which specifically reacts with mucus glycoproteins produced by human gastric gland-type mucous cells is provided. By performing immunohistochemical staining using a labeled derivative of the monoclonal antibody, human gastric gland-type mucous cells as well as mucus secreted by these cells can be specifically stained. The monoclonal antibody can also be used for the analysis of gastric gland-type mucous cell-derived mucus glycoproteins in human body fluids as well as for the examination or diagnosis of cancer.
Anticorps monoclonal de classe IgM réagissant spécifiquement avec la mucoglycoprotéine produite par des cellules muqueuses épithélioglandulaires gastriques humaines. Il est possible de colorer spécifiquement des cellules muqueuses épithélioglandulaires gastriques humaines ainsi que le mucus secrété par les cellules, par une coloration histologique immunologique à l'aide d'un dérivé marqué de l'anticorps précité. Il est également possible d'utiliser l'anticorps afin d'analyser des mucoglycoprotéines naissant dans les cellules muqueuses épithélioglandulaires gastriques contenues dans le liquide biologique humain, et afin d'examiner ou de diagnostiquer un cancer.
Hotta Kyoko
Ishihara Kazuhiko
Kurihara Makoto
Shimauchi Shiro
Tanaka Hiromi
Kanto Kagaku Kabushiki Kaisha
Kirby Eades Gale Baker
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