Anti-myostatin antibodies

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 16/22 (2006.01) A61K 39/395 (2006.01) A61P 21/00 (2006.01)

Patent

CA 2624976

A neutralizing epitope is identified within amino acids 40-64 of the mature form of human myostatin. Antibodies that bind this epitope with high affinity preferentially bind GDF-8 over GDF-11 and may be chimeric, humanized or fully human antibodies, immunoconjugates of the antibodies or antigen-binding fragments thereof. The antibodies of the invention are useful for increasing muscle mass, increasing bone density, or for the treatment of various disorders in mammalian and avian species.

L'invention concerne un épitope neutralisant identifié au sein des acides aminés 40 à 64 de la forme mature de la myostatine humaine. Les anticorps qui se lient à cet épitope avec une affinité élevée se lient de préférence à GDF-8 plutôt qu'à GDF-11 et peuvent être des anticorps chimériques, humanisés ou entièrement humains, des immunoconjugués de ces anticorps ou des fragments de ces anticorps se liant à l'antigène. Les anticorps selon l'invention peuvent être employés dans l'augmentation de la masse musculaire et de la densité osseuse, ainsi que dans le traitement de divers troubles d'espèces mammifères et aviaires.

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