C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 21/08 (2006.01) A61K 39/395 (2006.01) A61K 39/40 (2006.01) A61K 39/42 (2006.01) C07K 16/00 (2006.01)
Patent
CA 2558805
A neutralizing epitope is identified within amino acids 40-64 of the mature form of human myostatin. Antibodies that bind this epitope fall within the scope of the invention and may be murine, chimeric, or humanized antibodies, immunoconjugates of the antibodies or antigen-binding fragments thereof. The antibodies of the invention are useful for increasing muscle mass, increasing bone density, or for the treatment of various disorders in mammals.
Selon l'invention, un épitope de neutralisation est identifié dans les aminoacides 40-64 de la forme mature de la myostatine humaine. Les anticorps qui se lient à cet épitope relèvent du domaine d'application de la présente invention et peuvent être des anticorps murins, chimériques ou humanisés, des immunoconjugués des anticorps ou des fragments de liaison à l'antigène des anticorps. Les anticorps selon l'invention sont utiles pour augmenter la masse musculaire, augmenter la densité osseuse ou pour traiter divers troubles affectant les mammifères.
Carol Smith Rosamund
Han Bomie
Kay Kikly Kristine
Tobias Linda O.
Eli Lilly And Company
Gowling Lafleur Henderson Llp
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