C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/22 (2006.01) A61K 39/395 (2006.01) A61P 21/00 (2006.01)
Patent
CA 2661836
Monoclonal anti-myostatin antibodies that preferentially bind myostatin over GDF-11, have strong binding affinity to myostatin and are resistant to chemical degradation. The antibodies of the invention are useful for increasing muscle mass, increasing bone density, or for the treatment or prevention of various disorders in mammalian and avian species.
La présente invention concerne des anticorps anti-myostatine monoclonaux qui se lient de préférence à la myostatine plutôt qu'au facteur GDF-11, qui présentent une forte affinité de liaison à la myostatine et qui sont résistants à la dégradation chimique. Les anticorps de cette invention permettent d'accroître la masse musculaire et la densité osseuse et de traiter ou prévenir divers troubles chez des espèces mammifères et aviaires.
Huang Lihua
Sayers Robert Owen
Eli Lilly And Company
Gowling Lafleur Henderson Llp
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