Anti-neoplastic use of 1,4-bis (substituted aminoalkyl...

Details Anti-neoplastic use of 1,4-bis (substituted aminoalkyl... Anti-neoplastic use of 1,4-bis (substituted aminoalkyl...

C - Chemistry, Metallurgy

09

B

260/236.29

C09B 1/16 (2006.01) A61K 31/13 (2006.01) A61K 31/135 (2006.01) A61K 31/445 (2006.01) A61K 31/495 (2006.01) A61K 31/70 (2006.01) C07D 295/12 (2006.01)

Patent

CA 1143726

ABSTRACT OF THE DISCLOSURE Method for treating animal neoplasms by administering to a neoplasm-bearing animal host an antineoplastic amount of a 1,4-bis-substituted-9- 10-anthracenedione having the formula Image wherein W, X, Y and Z are each independently selected from the group consisting of hydrogen, OH, NH2, OCH3, N(CH3)2, F, Cl, Br, I, alkyl groups containing from 1-8 carbon atoms, glu- cosides, phenyl and substituted phenyl, and R is selected from the group consisting of alkyl amino groups containing from 1-8 carbon atoms, alkyl- aminoalkyl groups containing from 1-8 carbon atoms, substituted alkylamino-alkyl groups con- taining from 1-8 carbon atoms, and substituted aminoaryl groups.

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