Anti-neurodegenerative agents

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/495 (2006.01) A61K 31/454 (2006.01) A61K 31/496 (2006.01) A61P 25/00 (2006.01) A61P 25/14 (2006.01) A61P 25/16 (2006.01) A61P 25/28 (2006.01) C07D 295/14 (2006.01) C07D 413/04 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2500420

An anti-neurodegenerative agent useful in treating and preventing neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), spinal muscular atrophy (SMA), Huntinton~s disease, Parkinson~s disease, Alzheimer~s disease, dementia following cerebrovascular accident and other dementias associated with nerve loss which contains one or more compounds selected from the group consisting of 3-[4-(4-chlorophenyl)piperazin-1-yl]methyl]-1H- pyrrolo[2,3-b]pyridine or its salt, 5-(4-chlorophenyl)-4-methyl-3-(1-(2- phenylethyl)piperidin-4-yl)isoxazole or its salt, 3-(4-chlorophenyl)-4-methyl- 5-(1-(2-phenylethyl)piperidin-4-yl)isoxazole or its salt, and N-methyl-4-(2- cyanophenyl)piperazinyl-3-methylbenzamine or its salt.

L'invention concerne un agent antineurodégénératif utile pour traiter et prévenir des maladies neurodégénératives telles que la sclérose latérale amyotrophique, l'amyotrophie spinale, la maladie de Huntington, la maladie de Parkinson, la maladie d'Alzheimer, la démence consécutive à un accident vasculaire cérébral et d'autres démences associées à une perte neuronale. Cet agent contient un ou plusieurs composés sélectionnés dans le groupe constitué par 3-[4-chlorophényl)pipérazine-1-yl]méthyl]-1H-pyrrolo[2,3-b]pyridine ou son sel, 5-(4-chlorophényl)-4-méthyl-3-(1-(2-phényléthyl)pipéridine-4-yl)isoxazole ou son sel, 3-(4-chlorophényl)-4-méthyl-5(1-(2-phényléthyl)pipéridine-4-yl)isoxazole ou son sel et N-méthyl-4-(2-cyanophényl)pipérazinyl-3-méthylbenzamine ou son sel.

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