A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/4178 (2006.01) A61K 8/49 (2006.01) A61K 31/495 (2006.01) A61K 31/497 (2006.01) A61K 31/56 (2006.01) A61P 17/02 (2006.01) A61P 29/00 (2006.01) A61P 37/06 (2006.01)
Patent
CA 2268399
A novel use for the class of biologically active bis-heterocyclic, e.g., bis- indole alkaloid compounds, which have been named topsentins, bromotopsentins, homocarbonyltopsentins, nortopsentins, hamacanthins, bis-indole ethylamines, or dragmacidins, pharmaceutical compositions containing the compounds, methods of producing the compounds, and methods of using the compounds are disclosed. Specifically, the novel utility pertains to the anti-neurogenic inflammatory properties exhibited by the bis-indole compounds and their analogs.
L'invention concerne une nouvelle utilisation de la catégorie des composés biologiquement actifs bis-hétérocycliques, par ex. des bis-indole alcaloïdes, désignés sous l'appellation de topsentines, bromotopsentines, homocarbonyltopsentines, nortopsentines, hamacanthines, bis-indole éthylamines, ou dragmacidines. L'invention concerne également des compositions pharmaceutiques contenant lesdits composés, des procédés de production desdits composés, ainsi que des procédés d'utilisation desdits composés. Le caractère nouveau de l'invention réside en particulier dans les propriétés anti-inflammatoires antineurogènes des composés bis-indole et de leurs analogues.
Gunasekera Sarath P.
Jacobs Robert S.
Pomponi Shirley A.
Wright Amy E.
Harbor Branch Oceanographic Institution Inc.
Macrae & Co.
The Regents Of The University Of California
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