C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C12N 5/12 (2006.01) C12N 15/13 (2006.01)
Patent
CA 2666672
The present invention relates to agonist antibodies that specifically bind to Notch 3 and activate signaling. The present invention includes antibodies binding to an epitope comprising the first Lin12 domain. The present invention also includes uses of these antibodies to treat or prevent Notch 3 related diseases or disorders.
La présente mention concerne des anticorps d'agonistes qui se lient spécifiquement à Notch3 et activent la signalisation. Cette invention comprend des anticorps se liant à un épitope comprenant le premier domaine Lin 12. La présente invention comprend également l'utilisation de ces anticorps pour traiter ou prévenir des maladies ou troubles liés à Notch3.
Fung Sek Chung
Li Kang
Singh Sanjaya
Wu Wenjuan
Zhou Bin-Bing Stephen
Genentech Inc.
Smart & Biggar
LandOfFree
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