Anti-oral-microbial adhesion fraction derived from vaccinium

Details Anti-oral-microbial adhesion fraction derived from vaccinium Anti-oral-microbial adhesion fraction derived from vaccinium

A - Human Necessities

61

K

A61K 8/97 (2006.01) A61Q 11/00 (2006.01)

Patent

CA 2193583

A non-food oral hygiene composition comprising a suitable carrier and an effective amount of an adhesion inhibitory fraction isolated from juice from berries of the Vaccinium plant genus. In a preferred embodiment the anti-aggregation fraction is isolated from cranberry juice. It is characterized as being polymeric and having a molecular weight ~14,000; an elemental analysis of carbon 43-51%, hydrogen 4-5%, no nitrogen, no sulfur and no chlorine; an NMR line spectrum as set forth in Figures 2A and 2B; and an ultraviolet spectrum with an absorption peak at 280 nm in neutral or acidic pH solution which is absent in alkali solutions. This fraction exhibits adhesion inhibitory activity against both P fimbriated bacteria and oral bacteria.

Composition non alimentaire pour hygiène orale, renfermant un véhicule approprié et une quantité efficace d'une fraction anti-adhérence, isolée à partir d'un jus provenant des baies d'une plante du genre Vaccinium. Dans une version privilégiée, la fraction anti-agrégation est isolée à partir du jus de canneberge. Elle est de nature polymérique, avec une masse molaire de ~14000; Une analyse élémentaire révèle la présence de 43-51 % de carbone et de 4-5 % d'hydrogène, et l'absence d'azote, de soufre et de chlore; les figures 2A et 2B présentent le spectre RMN; le spectre dans l'UV montre un pic d'absorption à 280 nm dans une solution neutre ou acide, pic qui est absent dans les solutions alcalines. Cette fraction possède des propriétés d'anti-adhérence à la fois contre les bactéries P fimbriées et les bactéries orales.

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