Anti-osteopontin antibody and use thereof

Details Anti-osteopontin antibody and use thereof Anti-osteopontin antibody and use thereof

C - Chemistry, Metallurgy

07

K

C07K 16/18 (2006.01) A61K 39/395 (2006.01) A61K 45/00 (2006.01) A61P 19/02 (2006.01) A61P 29/00 (2006.01) A61P 37/02 (2006.01) A61P 43/00 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/52 (2006.01) C07K 16/24 (2006.01) C07K 16/28 (2006.01) C12N 15/09 (2006.01) C12P 21/08 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2443330

An anti-osteopontin antibody inhibiting the biding of an integrin to osteopontin or its fragment which inhibits the binding of the integrin recognizing RGD sequence to osteopontin or its fragment and recognizes SVVYGLR sequence or a sequence equivalent thereto. This antibody is useful in remedies for autoimmune diseases, remedies for rheumatism and remedies for rheumatoid arthritis. Also, a method of treating autoimmune disease, rheumatism or rheumatoid arthritis is provided. This antibody is useful in diagnostics and a diagnostic method for rheumatism too.

L'invention concerne un anticorps dirigé contre l'ostéopontine, inhibant la liaison d'une intégrine à l'ostéopontine ou son fragment, anticorps qui inhibe la liaison de la séquence RGD reconnaissant l'intégrine à l'ostéopontine ou son fragment et reconnaît la séquence SVVYGLR ou un équivalent de séquence de cette dernière. Cet anticorps est utile dans des remèdes contre les maladies autoimmunes, les rhumatismes ou l'arthrite rhumatoïde. L'invention concerne également une méthode de traitement des maladies autoimmunes, des rhumatismes ou de l'arthrite rhumatoïde. Cet anticorps est utile dans l'établissement de diagnostics et dans une méthode de diagnostic des rhumatismes.

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